Team: Season:
| Date | Opponent | Stadium | Results |
| Friday, Sept. 4 | at SMU | Gerald J. Ford Stadium | W 56-21 (1-0) |
| Saturday, Sept. 12 | Lamar | McLane Stadium | W 66-31 (2-0) |
| Saturday, Sept. 19 | Open Date | | |
| Saturday, Sept. 26 | Rice | McLane Stadium | W 70-17 (3-0) |
| Saturday, Oct. 3 | Texas Tech* | AT&T Stadium | W 63-35 (4-0) |
| Saturday, Oct. 10 | at Kansas* | Memorial Stadium | W 66-7 (5-0) |
| Saturday, Oct. 17 | West Virginia* | McLane Stadium | W 62-38 (6-0) |
| Saturday, Oct. 24 | Iowa State* | McLane Stadium | W 45-27 (7-0) |
| Saturday, Oct. 31 | Open Date | | |
| Thursday, Nov. 5 | at Kansas State* | Bill Snyder Family Football Stadium | W 31-24 (8-0) |
| Saturday, Nov. 14 | Oklahoma* | McLane Stadium | L 34-44 (8-1) |
| Saturday, Nov. 21 | at Oklahoma State* | Boone Pickens Stadium | W 45-35 (9-1) |
| Saturday, Nov. 28 | at TCU* | Amon G. Carter Stadium | L 21-28 (9-2) |
| Saturday, Dec. 5 | Texas* | McLane Stadium | L 17-23 (9-3) |
| Tuesday, Dec. 29 | vs. North Carolina | Orlando Citrus Bowl Stadium | W 49-38 (10-3) |
* – Conference Game
