Team:
| Date | Team | Time (ET) | TV | Results |
| Preseason | ||||
| Friday, Aug 14 | at Buffalo | 7:00 p.m. | Panthers TV | W 25-24 (1-0) |
| Saturday, Aug 22 | Miami | 7:00 p.m. | Panthers TV | W 31-30 (2-0) |
| Friday, Aug 28 | New England | 7:30 p.m. | Panthers TV | L 16-17 (2-1) |
| Thursday, Sept 3 | at Pittsburgh | 7:30 p.m. | Panthers TV | W 23-6 (3-1) |
| Regular Season | ||||
| Date | Team | Time (ET) | TV | Results |
| Sunday, Sept 13 | at Jacksonville | 1:00 p.m. | FOX | W 20-9 (1-0) |
| Sunday, Sept 20 | vs. Houston | 1:00 p.m. | CBS | W 24-17 (2-0) |
| Sunday, Sept 27 | vs. New Orleans | 1:00 p.m. | FOX | W 27-22 (3-0) |
| Sunday, Oct 4 | at Tampa Bay | 1:00 p.m. | FOX | W 37-23 (4-0) |
| Sunday, Oct 11 | Bye Week | |||
| Sunday, Oct 18 | at Seattle | 4:05 p.m. | FOX | W 27-23 (5-0) |
| Sunday, Oct 25 | vs. Philadelphia | 8:30 p.m. | NBC | W 27-16 (6-0) |
| Monday, Nov 2 | vs. Indianapolis | 8:30 p.m. | ESPN | W 29-26 OT (7-0) |
| Sunday, Nov 8 | vs. Green Bay | 1:00 p.m. | FOX | W 37-29 (8-0) |
| Sunday, Nov 15 | at Tennessee | 1:00 p.m. | FOX | W 27-10 (9-0) |
| Sunday, Nov 22 | vs. Washington | 1:00 p.m. | FOX | W 44-16 (10-0) |
| Thursday, Nov 26 | at Dallas | 4:30 p.m. | CBS | W 33-14 (11-0) |
| Sunday, Dec 6 | at New Orleans | 1:00 p.m. | FOX | W 41-38 (12-0) |
| Sunday, Dec 13 | vs. Atlanta | 1:00 p.m. | FOX | W 38-0 (13-0) |
| Sunday, Dec 20 | at New York | 1:00 p.m. | FOX | W 38-35 (14-0) |
| Sunday, Dec 27 | at Atlanta | 1:00 p.m. | FOX | L 13-20 (14-1) |
| Sunday, Jan 3 | vs. Tampa Bay | 1:00 p.m. | FOX | W 38-10 (15-1) |
| Postseason | ||||
| Date | Team | Time (ET) | TV | Results |
| Sunday, Jan 17 | vs. Seattle | 1:05 p.m. | FOX | W 31-24 |
| Sunday, Jan 24 | vs. Arizona | 5:40 | FOX | W 49-15 |
| Sunday, Feb 7 | vs. Denver* | 5:30 | CBS | L 10-24 |
*Super Bowl