Team: Season:
| Date | Opponent | Stadium | Results |
| Saturday, Sept. 5 | Tennessee Tech | TDECU Stadium | W 52-24 (1-0) |
| Saturday, Sept. 12 | at Louisville | Papa John's Cardinal Stadium | W 34-31 (2-0) |
| Saturday, Sept. 19 | Open Date | | |
| Saturday, Sept. 26 | Texas State | TDECU Stadium | W 59-14 (3-0) |
| Saturday, Oct. 3 | at Tulsa | H.A. Chapman Stadium | W 38-24 (4-0) |
| Thursday, Oct. 8 | SMU | TDECU Stadium | W 49-28 (5-0) |
| Friday, Oct. 16 | at Tulane | Yulman Stadium | W 42-7 (6-0) |
| Saturday, Oct. 24 | at UCF | Bright House Networks Stadium | W 59-10 (7-0) |
| Saturday, Oct. 31 | Vanderbilt | TDECU Stadium | W 34-0 (8-0) |
| Saturday, Nov. 7 | Cincinnati | TDECU Stadium | W 33-30 (9-0) |
| Saturday, Nov. 14 | Memphis | TDECU Stadium | W 35-34 (10-0) |
| Saturday, Nov. 21 | at Connecticut | Rentschler Field | L 17-20 (10-1) |
| Friday, Nov. 27 | Navy | TDECU Stadium | W 52-31 (11-1) |
| Saturday, Dec. 5 | Temple | TDECU Stadium | W 24-13 (12-1) |
| Thursday, Dec. 31 | vs. Florida State | Georgia Dome | W 38-24 (13-1) |
