Team: Season:
| Date | Opponent | Stadium | Results |
| Saturday, Sept. 5 | Illinois State | Kinnick Stadium | W 31-14 (1-0) |
| Saturday, Sept. 12 | at Iowa State | Jack Trice Stadium | W 31-17 (2-0) |
| Saturday, Sept. 19 | Pittsburgh | Kinnick Stadium | W 27-24 (3-0) |
| Saturday, Sept. 26 | North Texas | Kinnick Stadium | W 62-16 (4-0) |
| Saturday, Oct. 3 | at Wisconsin | Camp Randall Stadium | W 10-6 (5-0) |
| Saturday, Oct. 10 | Illinois | Kinnick Stadium | W 29-20 (6-0) |
| Saturday, Oct. 17 | at Northwestern | Ryan Field | W 40-10 (7-0) |
| Saturday, Oct. 24 | Open Date | | |
| Saturday, Oct. 31 | Maryland | Kinnick Stadium | W 31-15 (8-0) |
| Saturday, Nov. 7 | at Indiana | Memorial Stadium | W 35-27 (9-0) |
| Saturday, Nov. 14 | Minnesota | Kinnick Stadium | W 40-35 (10-0) |
| Saturday, Nov. 21 | Purdue | Kinnick Stadium | W 40-20 (11-0) |
| Friday, Nov. 27 | at Nebraska | Memorial Stadium | W 28-20 (12-0) |
| Saturday, Dec. 5 | vs. Michigan State | Lucas Oil Stadium | L 13-16 (12-1) |
| Friday, Jan. 1 | vs. Stanford | Rose Bowl | L 16-45 (12-2) |
