Team: Season:
| Date | Opponent | Stadium | Results |
| Friday, Sept. 4 | at Western Michigan | Waldo Stadium | W 37-24 (1-0) |
| Saturday, Sept. 12 | Oregon | Spartan Stadium | W 31-28 (2-0) |
| Saturday, Sept. 19 | Air Force | Spartan Stadium | W 35-21 (3-0) |
| Saturday, Sept. 26 | Central Michigan | Spartan Stadium | W 30-10 (4-0) |
| Saturday, Oct. 3 | Purdue* | Spartan Stadium | W 24-21 (5-0) |
| Saturday, Oct. 10 | at Rutgers * | High Point Solutions Stadium | W 31-24 (6-0) |
| Saturday, Oct. 17 | at Michigan** | Michigan Stadium | W 27-23 (7-0) |
| Saturday, Oct. 24 | Indiana** (HC) | Spartan Stadium | W 52-26 (8-0) |
| Saturday, Oct. 31 | Open Date | | |
| Saturday, Nov. 7 | at Nebraska* | Memorial Stadium | L 38-39 (8-1) |
| Saturday, Nov. 14 | Maryland* | Spartan Stadium | W 24-7 (9-1) |
| Saturday, Nov. 21 | at Ohio State* | Ohio Stadium | W 17-14 (10-1) |
| Saturday, Nov. 28 | Penn State** | Spartan Stadium | W 55-16 (11-1) |
| Saturday, Dec. 5 | vs. Iowa | Lucas Oil Stadium | W 16-13 (12-1) |
| Thursday, Dec. 31 | vs. Alabama | AT&T Stadium | L 0-38 (12-2) |
** – Rivalry and Conference Game
* – Conference Game
