Team: Season:
| Date | Opponent | Stadium | Results |
| Thursday, Sept. 3 | TCU | TCF Bank Stadium | L 17-23 (0-1) |
| Saturday, Sept. 12 | at Colorado | Hughes Stadium | W 23-20 OT (1-1) |
| Saturday, Sept. 19 | Kent State | TCF Bank Stadium | W 10-7 (2-1) |
| Saturday, Sept. 26 | Ohio | TCF Bank Stadium | W 27-24 (3-1) |
| Saturday, Oct. 3 | at Northwestern | Ryan Field | L 0-27 (3-2) |
| Saturday, Oct. 10 | at Purdue | Ross-Ade Stadium | W 41-13 (4-2) |
| Saturday, Oct. 17 | Nebraska | TCF Bank Stadium | L 25-48 (4-3) |
| Saturday, Oct. 24 | Open Date | | |
| Saturday, Oct. 31 | Michigan | TCF Bank Stadium | L 26-29 (4-4) |
| Saturday, Nov. 7 | at Ohio State | Ohio Stadium | L 14-28 (4-5) |
| Saturday, Nov. 14 | at Iowa | Kinnick Stadium | L 35-40 (4-6) |
| Saturday, Nov. 21 | Illinois | TCF Bank Stadium | W 32-23 (5-6) |
| Saturday, Nov. 28 | Wisconsin | TCF Bank Stadium | L 21-31 (5-7) |
| Monday, Dec. 28 | vs. Central Michigan | Ford Field | W 21-14 (6-7) |
