Team:
| Date | Team | Time (ET) | TV | Results |
| Preseason | ||||
| Friday, Aug 14 | St. Louis | 10:00 p.m. | KTVU/KICU | W 18-3 (1-0) |
| Saturday, Aug 22 | at Minnesota | 8:00 p.m. | KTVU/KICU | L 12-20 (1-1) |
| Sunday, Aug 30 | Arizona | 8:00 p.m. | NBC | L 23-30 (1-2) |
| Thursday, Sept 3 | at Seattle | 10:00 p.m. | KTVU/KICU | L 21-31 (1-3) |
| Regular Season | ||||
| Date | Team | Time (ET) | TV | Results |
| Sunday, Sept 13 | vs. Cincinnati | 4:25 p.m. | CBS | L 13-33 (0-1) |
| Sunday, Sept 20 | vs. Baltimore | 4:05 p.m. | CBS | W 37-33 (1-1) |
| Sunday, Sept 27 | at Cleveland | 1:00 p.m. | CBS | W 27-20 (2-1) |
| Sunday, Oct 4 | at Chicago | 1:00 p.m. | CBS | L 20-22 (2-2) |
| Sunday, Oct 11 | at Denver | 4:25 p.m. | CBS | L 10-16 (2-3) |
| Sunday, Oct 18 | Bye Week | |||
| Sunday, Oct 25 | at San Diego | 4:05 p.m. | CBS | W 37-29 (3-3) |
| Sunday, Nov 1 | vs. New York Jets | 4:05 p.m. | CBS | W 34-20 (4-3) |
| Sunday, Nov 8 | at Pittsburgh | 1:00 p.m. | CBS | L 35-38 (4-4) |
| Sunday, Nov 15 | vs. Minnesota | 4:05 p.m. | Fox | L 14-30 (4-5) |
| Sunday, Nov 22 | at Detroit | 1:00 p.m. | CBS | L 13-18 (4-6) |
| Sunday, Nov 29 | at Tennessee | 1:00 p.m. | CBS | W 24-21 (5-6) |
| Sunday, Dec 6 | vs. Kansas City | 4:05 p.m. | CBS | L 20-34 (5-7) |
| Sunday, Dec 13 | at Denver | 4:05 p.m. | CBS | W 15-12 (6-7) |
| Sunday, Dec 20 | vs. Green Bay | 4:05 p.m. | Fox | L 20-30 (6-8) |
| Thursday, Dec 24 | vs. San Diego | 8:25 p.m. | NFL Network | W 23-20 OT (7-8) |
| Sunday, Jan 3 | at Kansas City | 1:00 p.m. | CBS | L 17-23 (7-9) |