Team: Season:
| Date | Opponent | Stadium | Results |
| Saturday, Sept. 5 | Akron | Gaylord Family Oklahoma Memorial Stadium | W 41-3 (1-0) |
| Saturday, Sept. 12 | at Tennessee | Neyland Stadium | W 31-24 OT (2-0) |
| Saturday, Sept. 19 | Tulsa | Gaylord Family Oklahoma Memorial Stadium | W 52-38 (3-0) |
| Saturday, Sept. 26 | Open Date | | |
| Saturday, Oct. 3 | West Virginia | Gaylord Family Oklahoma Memorial Stadium | W 44-24 (4-0) |
| Saturday, Oct. 10 | Texas | Cotton Bowl | L 17-24 (4-1) |
| Saturday, Oct. 17 | at Kansas State | Bill Snyder Family Football Stadium | W 55-0 (5-1) |
| Saturday, Oct. 24 | Texas Tech | Gaylord Family Oklahoma Memorial Stadium | W 63-27 (6-1) |
| Saturday, Oct. 31 | at Kansas | Memorial Stadium | W 62-7 (7-1) |
| Saturday, Nov. 7 | Iowa State | Gaylord Family Oklahoma Memorial Stadium | W 52-16 (8-1) |
| Saturday, Nov. 14 | at Baylor | McLane Stadium | W 44-34 (9-1) |
| Saturday, Nov. 21 | TCU | Gaylord Family Oklahoma Memorial Stadium | W 30-29 (10-1) |
| Saturday, Nov. 28 | at Oklahoma State | Boone Pickens Stadium | W 58-23 (11-1) |
| Thursday, Dec. 31 | vs. Clemson | Sun Life Stadium | L 17-37 (11-2) |
* – Conference
