Team: Season:
| Date | Opponent | Stadium | Results |
| Saturday, Sept. 5 | Norfolk State | High Point Solutions Stadium | W 63-13 (1-0) |
| Saturday, Sept. 12 | Washington State | High Point Solutions Stadium | L 34-37 (1-1) |
| Saturday, Sept. 19 | at Penn State | Beaver Stadium | L 3-28 (1-2) |
| Saturday, Sept. 26 | Kansas | High Point Solutions Stadium | W 27-14 (2-2) |
| Saturday, Oct. 3 | Open Date | | |
| Saturday, Oct. 10 | Michigan State | High Point Solutions Stadium | L 24-31 (2-3) |
| Saturday, Oct. 17 | at Indiana | Memorial Stadium | W 55-52 (3-3) |
| Saturday, Oct. 24 | Ohio State | High Point Solutions Stadium | L 7-49 (3-4) |
| Saturday, Oct. 31 | at Wisconsin | Camp Randall Stadium | L 10-48 (3-5) |
| Saturday, Nov. 7 | at Michigan | Michigan Stadium | L 16-49 (3-6) |
| Saturday, Nov. 14 | Nebraska | High Point Solutions Stadium | L 14-31 (3-7) |
| Saturday, Nov. 21 | at Army | Michie Stadium | W 31-21 (4-7) |
| Saturday, Nov. 28 | Maryland | High Point Solutions Stadium | L 41-46 (4-8) |
