Team: Season:
| Date | Opponent | Stadium | Results |
| Saturday, Sept. 5 | Penn State | Lincoln Financial Field | W 27-10 (1-0) |
| Saturday, Sept. 12 | at Cincinnati | Nippert Stadium | W 34-26 (2-0) |
| Saturday, Sept. 19 | at UMass | Gillette Stadium | W 25-23 (3-0) |
| Saturday, Sept. 26 | Open Date | | |
| Friday, Oct. 2 | at Charlotte | Jerry Richardson Stadium | W 37-3 (4-0) |
| Saturday, Oct. 10 | Tulane | Lincoln Financial Field | W 49-10 (5-0) |
| Saturday, Oct. 17 | UCF | Lincoln Financial Field | W 30-16 (6-0) |
| Thursday, Oct. 22 | at East Carolina | Dowdy-Ficklen Stadium | W 24-14 (7-0) |
| Saturday, Oct. 31 | Notre Dame | Lincoln Financial Field | L 20-24 (7-1) |
| Friday, Nov. 6 | at SMU | Gerald J. Ford Stadium | W 60-40 (8-1) |
| Saturday, Nov. 14 | at South Florida | Raymond James Stadium | L 23-44 (8-2) |
| Saturday, Nov. 21 | Memphis | Lincoln Financial Field | W 31-12 (9-2) |
| Saturday, Nov. 28 | UConn | Lincoln Financial Field | W 27-3 (10-2) |
| Saturday, Dec. 5 | at Houston | TDECU Stadium | L 13-24 (10-3) |
| Tuesday, Dec. 22 | vs. Toledo | FAU Stadium | L 17-32 (10-4) |
