Team: Season:
| Date | Opponent | Stadium | Results |
| Saturday, Sept. 5 | Bowling Green | Nissan Stadium | W 59-30 (1-0) |
| Saturday, Sept. 12 | Oklahoma | Neyland Stadium | L 24-31 OT (1-1) |
| Saturday, Sept. 19 | Western Carolina | Neyland Stadium | W 55-10 (2-1) |
| Saturday, Sept. 26 | at Florida | Ben Hill Griffin Stadium | L 27-28 (2-2) |
| Saturday, Oct. 3 | Arkansas | Neyland Stadium | L 20-24 (2-3) |
| Saturday, Oct. 10 | Georgia | Neyland Stadium | W 38-31 (3-3) |
| Saturday, Oct. 17 | Open Date | | |
| Saturday, Oct. 24 | at Alabama | Bryant-Denny Stadium | L 14-19 (3-4) |
| Saturday, Oct. 31 | at Kentucky | Commonwealth Stadium | W 52-21 (4-4) |
| Saturday, Nov. 7 | South Carolina | Neyland Stadium | W 27-24 (5-4) |
| Saturday, Nov. 14 | North Texas | Neyland Stadium | W 24-0 (6-4) |
| Saturday, Nov. 21 | at Missouri | Faurot Field | W 19-8 (7-4) |
| Saturday, Nov. 28 | Vanderbilt | Neyland Stadium | W 53-28 (8-4) |
| Friday, Jan. 1 | vs. Northwestern | Orlando Citrus Bowl Stadium | W 45-6 (9-4) |
