Team: Season:
| Date | Opponent | Stadium | Time (ET)/TV | Tickets/Results |
| Saturday, Sept. 3 | Murray State | Memorial Stadium | 3:30 p.m./BTN | W 52-3 (1-0) |
| Saturday, Sept. 10 | North Carolina | Memorial Stadium | 7:30 p.m./BTN | |
| Saturday, Sept. 17 | Western Michigan | Memorial Stadium | 4:00 p.m./ESPNews | |
| Saturday, Sept. 24 | Open Date | | | |
| Saturday, Oct. 1 | at Nebraska | Memorial Stadium | 3:30 p.m./TBA | |
| Saturday, Oct. 8 | Purdue | Memorial Stadium | TBA | |
| Saturday, Oct. 15 | at Rutgers | High Point Solutions Stadium | 12:00 p.m./TBA | |
| Saturday, Oct. 22 | at Michigan | Michigan Stadium | 3:30 p.m./TBA | |
| Saturday, Oct. 29 | Minnesota | Memorial Stadium | 12:00 p.m./TBA | |
| Saturday, Nov. 5 | Michigan State | Memorial Stadium | TBA | |
| Saturday, Nov. 12 | at Wisconsin | Camp Randall Stadium | 3:30 p.m./TBA | |
| Saturday, Nov. 19 | Iowa | Memorial Stadium | TBA | |
| Saturday, Nov. 26 | at Northwestern | Ryan Field | TBA | |
| Saturday, Dec. 3 | Big Ten Championship Game | Lucas Oil Stadium | 8:00 p.m./FOX | |
