Team: Season:
| Date | Opponent | Stadium | Time (ET)/TV | Tickets/Results |
| Saturday, Sept. 3 | Miami (OH) | Kinnick Stadium | 3:30 p.m./ESPNU | W 45-21 (1-0) |
| Saturday, Sept. 10 | Iowa State | Kinnick Stadium | 7:30 p.m./BTN | |
| Saturday, Sept. 17 | North Dakota State | Kinnick Stadium | 12:00 p.m./TBA | |
| Saturday, Sept. 24 | at Rutgers | High Point Solutions Stadium | TBA | |
| Saturday, Oct. 1 | Northwestern | Kinnick Stadium | 12:00 p.m./TBA | |
| Saturday, Oct. 8 | at Minnesota | TCF Bank Stadium | TBA | |
| Saturday, Oct. 15 | at Purdue | Ross-Ade Stadium | 12:00 p.m./TBA | |
| Saturday, Oct. 22 | Wisconsin | Kinnick Stadium | TBA | |
| Saturday, Oct. 29 | Open Date | | | |
| Saturday, Nov. 5 | at Penn State | Beaver Stadium | 7:30 p.m./BTN | |
| Saturday, Nov. 12 | Michigan | Kinnick Stadium | 8:00 p.m./TBA | |
| Saturday, Nov. 19 | at Illinois | Memorial Stadium | TBA | |
| Friday, Nov. 25 | Nebraska | Kinnick Stadium | TBA | |
| Saturday, Dec. 3 | Big Ten Championship Game | Lucas Oil Stadium | 8:00 p.m./FOX | |
