Team: Season:
| Date | Opponent | Stadium | Time (ET)/TV | Tickets/Results |
|---|---|---|---|---|
| Thursday, Sept. 1 | Charlotte | Papa John's Cardinal Stadium | 7:00 p.m./ACCN Extra | W 70-14 (1-0) |
| Friday, Sept. 9 | at Syracuse | Carrier Dome | 8:00 p.m./ESPN2 | W 62-28 (2-0) |
| Saturday, Sept. 17 | Florida State | Papa John's Cardinal Stadium | 12:00 p.m./ABC | W 63-20 (3-0) |
| Saturday, Sept. 24 | at Marshall | Joan C. Edwards Stadium | 8:00 p.m./CBSSN | W 59-28 (4-0) |
| Saturday, Oct. 1 | at Clemson | Memorial Stadium | 8:00 p.m./ABC | L 36-42 (4-1) |
| Saturday, Oct. 8 | Bye Week | |||
| Friday, Oct. 14 | Duke | Papa John's Cardinal Stadium | 7:00 p.m./ESPN | W 24-14 (5-1) |
| Saturday, Oct. 22 | NC State | Papa John's Cardinal Stadium | 12:00 p.m./ABC | W 54-13 (6-1) |
| Saturday, Oct. 29 | at Virginia | Scott Stadium | 12:00 p.m./ABC or ESPN2 | W 32-25 (7-1) |
| Saturday, Nov. 5 | at Boston College | Alumni Stadium | 12:00 p.m./ESPN2 | W 52-7 (8-1) |
| Saturday, Nov. 12 | Wake Forest | Papa John's Cardinal Stadium | 7:00 p.m./ESPN2 | |
| Thursday, Nov. 17 | at Houston | TDECU Stadium | 8:00 p.m./ESPN | |
| Saturday, Nov. 26 | Kentucky | Papa John's Cardinal Stadium | TBA | |
| Saturday, Dec. 3 | ACC Championship Game | Bank of America Stadium | TBA |