Team: Season:
| Date | Opponent | Stadium | Time (ET)/TV | Tickets/Results |
| Friday, Sept. 2 | Furman | Spartan Stadium | 7:00 p.m./BTN | W 28-13 |
| Saturday, Sept. 10 | Bye Week | | | |
| Saturday, Sept. 17 | at Notre Dame | Notre Dame Stadium | 7:30 p.m./NBC | |
| Saturday, Sept. 24 | Wisconsin | Spartan Stadium | TBA | |
| Saturday, Oct. 1 | at Indiana | Memorial Stadium | 8:00 p.m./BTN | |
| Saturday, Oct. 8 | BYU | Spartan Stadium | TBA | |
| Saturday, Oct. 15 | Northwestern | Spartan Stadium | 3:30 p.m./TBA | |
| Saturday, Oct. 22 | at Maryland | Maryland Stadium | 7:30 p.m./BTN | |
| Saturday, Oct. 29 | Michigan | Spartan Stadium | TBA | |
| Saturday, Nov. 5 | at Illinois | Memorial Stadium | TBA | |
| Saturday, Nov. 12 | Rutgers | Spartan Stadium | TBA | |
| Saturday, Nov. 19 | Ohio State | Spartan Stadium | TBA | |
| Saturday, Nov. 26 | at Penn State | Beaver Stadium | TBA | |
| Saturday, Dec. 3 | Big Ten Championship Game | Lucas Oil Stadium | 8:00 p.m./FOX | |
