Team: Season:
| Date | Opponent | Stadium | Time (ET)/TV | Tickets/Results |
| Saturday, Sept. 3 | Western Michigan | Ryan Field | 12:00 p.m./ESPNU | L 21-22 (0-1) |
| Saturday, Sept. 10 | Illinois State | Ryan Field | 3:30 p.m./BTN | |
| Saturday, Sept. 17 | Duke | Ryan Field | 8:00 p.m./BTN | |
| Saturday, Sept. 24 | Nebraska | Ryan Field | 7:30 p.m./BTN | |
| Saturday, Oct. 1 | at Iowa | Kinnick Stadium | 12:00 p.m./TBA | |
| Saturday, Oct. 8 | Open Date | | | |
| Saturday, Oct. 15 | at Michigan State | Spartan Stadium | 3:30 p.m./TBA | |
| Saturday, Oct. 22 | Indiana | Ryan Field | 12:00 p.m./TBA | |
| Saturday, Oct. 29 | at Ohio State | Ohio Stadium | 5:30 p.m./TBA | |
| Saturday, Nov. 5 | Wisconsin | Ryan Field | TBA | |
| Saturday, Nov. 12 | at Purdue | Ross-Ade Stadium | TBA | |
| Saturday, Nov. 19 | at Minnesota | TCF Bank Stadium | TBA | |
| Saturday, Nov. 26 | Illinois | Ryan Field | TBA | |
| Saturday, Dec. 3 | Big Ten Championship Game | Lucas Oil Stadium | 8:00 p.m./FOX | |
