Team: Season:
| Date | Opponent | Stadium | Time (ET)/TV | Tickets/Results |
| Saturday, Sept. 3 | Kent State | Beaver Stadium | 3:30 p.m./BTN | W 33-13 |
| Saturday, Sept. 10 | at Pittsburgh | Heinz Field | 12:00 p.m./ESPN | |
| Saturday, Sept. 17 | Temple | Beaver Stadium | 12:00 p.m./BTN | |
| Saturday, Sept. 24 | Open Date | | | |
| Saturday, Oct. 1 | Minnesota | Beaver Stadium | TBA | |
| Saturday, Oct. 8 | Maryland | Beaver Stadium | 12:00 p.m./TBA | |
| Saturday, Oct. 15 | at Michigan | Michigan Stadium | TBA | |
| Saturday, Oct. 22 | Ohio State | Beaver Stadium | 8:00 p.m./TBA | |
| Saturday, Oct. 29 | at Purdue | Ross-Ade Stadium | TBA | |
| Saturday, Nov. 5 | Iowa | Beaver Stadium | TBA | |
| Saturday, Nov. 12 | at Indiana | Memorial Stadium | 7:30 p.m./BTN | |
| Saturday, Nov. 19 | at Rutgers | High Point Solutions Stadium | 8:00 p.m./BTN | |
| Saturday, Nov. 26 | Michigan State | Beaver Stadium | TBA | |
| Saturday, Dec. 3 | Big Ten Championship Game | Lucas Oil Stadium | 8:00 p.m./FOX | |
