Team: Season:
| Date | Opponent | Stadium | Time (ET)/TV | Tickets/Results |
| Saturday, Sept. 3 | Alabama | AT&T Stadium | 8:00 p.m./ABC | L 6-52 (0-1) |
| Saturday, Sept. 10 | Utah State | LA Memorial Coliseum | 2:00 p.m./Pac-12N | W 45-7 (1-1) |
| Saturday, Sept. 17 | at Stanford | Stanford Stadium | 8:00 p.m./ABC | L 10-27 (1-2) |
| Friday, Sept. 23 | at Utah | Rice-Eccles Stadium | 9:00 p.m./FS1 | |
| Saturday, Oct. 1 | Arizona State | LA Memorial Coliseum | TBA | |
| Saturday, Oct. 8 | Colorado | LA Memorial Coliseum | TBA | |
| Saturday, Oct. 15 | at Arizona | Arizona Stadium | TBA | |
| Saturday, Oct. 22 | Bye Week | | | |
| Thursday, Oct. 27 | Cal | LA Memorial Coliseum | 10:30 p.m./ESPN | |
| Saturday, Nov. 5 | Oregon | LA Memorial Coliseum | TBA | |
| Saturday, Nov. 12 | at Washington | Husky Stadium | TBA | |
| Saturday, Nov. 19 | at UCLA | Rose Bowl | TBA | |
| Saturday, Nov. 26 | Notre Dame | LA Memorial Coliseum | TBA | |
| Friday, Dec. 2 | Pac-12 Championship Game | Levi's Stadium | 9:00 p.m./FOX | |
