Season:
| Date | Rank | Opponent | Stadium | Results (Time/TV) | History |
|---|---|---|---|---|---|
| Saturday, Sept. 4 | #1 | #14 Miami (FL) | Mercedes-Benz Stadium | W 44-13 (1-0) | Series |
| Saturday, Sept. 11 | #1 | Mercer | Bryant-Denny Stadium | W 48-14 (2-0) | |
| Saturday, Sept. 18 | #1 | at #11 Florida | Ben Hill Griffin Stadium | W 31-29 (3-0) | Series |
| Saturday, Sept. 25 | #1 | Southern Miss | Bryant-Denny Stadium | W 63-14 (4-0) | Series |
| Saturday, Oct. 2 | #1 | #12 Ole Miss | Bryant-Denny Stadium | W 42-21 (5-0) | Series |
| Saturday, Oct. 9 | #1 | at Texas A&M | Kyle Field | L 38-41 (5-1) | Series |
| Saturday, Oct. 16 | #5 | at Mississippi State | Davis Wade Stadium | W 49-9 (6-1) | Series |
| Saturday, Oct. 23 | #4 | Tennessee | Bryant-Denny Stadium | W 52-24 (7-1) | Series |
| Saturday, Nov. 6 | #2 | LSU | Bryant-Denny Stadium | W 20-14 (8-1) | Series |
| Saturday, Nov. 13 | #2 | New Mexico State | Bryant-Denny Stadium | W 59-3 (9-1) | Series |
| Saturday, Nov. 20 | #2 | #21 Arkansas | Bryant-Denny Stadium | W 42-35 (10-1) | Series |
| Saturday, Nov. 27 | #3 | at Auburn | Jordan-Hare Stadium | W 24-22 4OT (11-1) | Series |
| Saturday, Dec. 4 | #3 | vs #1 Georgia | Mercedes-Benz Stadium | W 41-24 (12-1) | Series |
| Friday, Dec. 31 | #1 | vs #4 Cincinnati | AT&T Stadium | W 27-6 (13-1) | Series |
| Monday, Jan. 10 | #1 | vs #3 Georgia | Lucas Oil Stadium | L 18-33 (13-2) | Series |