Season:
2022 →
| Date | Rank | Opponent | Stadium | Results (Time/TV) | |
|---|---|---|---|---|---|
| September 2 | NR | Bowling Green | Neyland Stadium | W 38–6 (1-0) | |
| September 11 | NR | Pittsburgh | Neyland Stadium | L 34–41 (1-1) | |
| September 18 | NR | Tennessee Tech | Neyland Stadium | W 56–0 (2-1) | |
| September 25 | NR | at #11 Florida | Ben Hill Griffin Stadium | L 14–38 (2-2) | |
| October 2 | NR | at Missouri | Faurot Field | W 62–24 (3-2) | |
| October 9 | NR | South Carolina | Neyland Stadium | W 45–20 (4-2) | |
| October 16 | NR | #13 Ole Miss | Neyland Stadium | L 26-31 (4-3) | |
| October 23 | NR | at #4 Alabama | Bryant-Denny Stadium | L 24-52 (4-4) | |
| November 6 | NR | at #18 Kentucky | Kroger Field | W 45-42 (5-4) | |
| November 13 | NR | #1 Georgia | Neyland Stadium | L 17-41 (5-5) | |
| November 20 | NR | South Alabama | Neyland Stadium | W 60–14 (6-5) | |
| November 27 | NR | Vanderbilt | Neyland Stadium | W 45–21 (7-5) | |
| December 30 | NR | vs Purdue | Nissan Stadium | L 45-48 (7-6) | |