Season:
| Date | Rank | Opponent | Stadium | Time (ET)/TV | Results |
|---|---|---|---|---|---|
| Saturday, Sept. 3 | #2 | #5 Notre Dame | Ohio Stadium | 7:30 p.m./ABC | W 21-10 (1-0) |
| Saturday, Sept. 10 | #3 | Arkansas State | Ohio Stadium | 12:00 p.m./BTN | W 45-12 (2-0) |
| Saturday, Sept. 17 | #3 | Toledo | Ohio Stadium | 7:00 p.m./FOX | W 77-21 (3-0) |
| Saturday, Sept. 24 | #3 | Wisconsin | Ohio Stadium | 7:30 p.m./ABC | W 52-21 (4-0) |
| Saturday, Oct. 1 | #3 | Rutgers | Ohio Stadium | 3:30 p.m./TBA | W 49-10 (5-0) |
| Saturday, Oct. 8 | #3 | at Michigan State | Spartan Stadium | 4:00 p.m./ABC | W 49-20 (6-0) |
| Saturday, Oct. 22 | #2 | Iowa | Ohio Stadium | 12:00 p.m./FOX | |
| Saturday, Oct. 29 | at Penn State | Beaver Stadium | 12:00 p.m./FOX | ||
| Saturday, Nov. 5 | at Northwestern | Ryan Field | TBA | ||
| Saturday, Nov. 12 | Indiana | Ohio Stadium | TBA | ||
| Saturday, Nov. 19 | at Maryland | Maryland Stadium | TBA | ||
| Saturday, Nov. 26 | Michigan | Ohio Stadium | 12:00 p.m./FOX | ||
| Saturday, Dec. 3 | Big Ten Championship Game | Lucas Oil Stadium | TBA |