Season:
| Date | Opponent | Stadium | Time (CT)/TV | Results |
|---|---|---|---|---|
| Saturday, Aug. 27 | at Hawaii | Ching Complex | 9:30 p.m./CBSSn | W 63-10 (1-0) |
| Saturday, Sept. 3 | Elon | Vanderbilt Stadium | 6:00 p.m./SECN+ | W 42-31 (2-0) |
| Saturday, Sept. 10 | #23 Wake Forest | Vanderbilt Stadium | 11:00 a.m./SECN | L 25-45 (2-1) |
| Saturday, Sept. 17 | at Northern Illinois | Huskie Stadium | 2:30 p.m./CBSSN | W 38-28 (3-1) |
| Saturday, Sept. 24 | at #2 Alabama | Bryant-Denny Stadium Stadium | 6:30 p.m./SECN | L 3-55 (3-2) |
| Saturday, Oct. 8 | #9 Ole Miss | Vanderbilt Stadium | 3:00 p.m./SECN | L 27-52 (3-3) |
| Saturday, Oct. 15 | at #1 Georgia | Sanford Stadium | 2:30 p.m./SECN | L 0-55 (3-4) |
| Saturday, Oct. 22 | at Missouri | Faurot Field | 3:00 p.m./SECN | |
| Saturday, Nov. 5 | South Carolina | Vanderbilt Stadium | TBA | |
| Saturday, Nov. 12 | at Kentucky | Kroger Field | TBA | |
| Saturday, Nov. 19 | Florida | Vanderbilt Stadium | TBA | |
| Saturday, Nov. 26 | Tennessee | Vanderbilt Stadium | TBA | |
| Saturday, Dec. 3 | SEC Championship Game | Mercedes-Benz Stadium | TBA |